Department of Biotechnology (DBT) was set up in February, 1986 and the NBTB selected Dr S Ramachandran as the first Secretary of the department. The DBTconstituted a ten member Scientific Advisory Committee (SAC) with heads of various scientific agencies and a seven member Standing Advisory Committee for North America SAC (0) to ensure that the Department kept abreast of global developments in the field ofBiotechnology.
Background : Generation of large scale biological data by high-throughput platforms particularly with the advent of the new generation sequencing platforms has contributed to a paradigm shift in biological research. This high volume of data represents only one aspect of big data. This data is further complicated by its high-velocity of generation and highly heterogeneous/unstructured nature. The prospect of utilizing this data for addressing scientific problems in biomedical/ agricultural or ecological research is exciting. However, the success greatly depends on developing new and efficient tools/pipelines/software packages for big data handling, analysis, integration, interpretation and visualization.
Purpose: The purpose of this call is to solicit R&D proposals towards development of computational tools, pipelines, newer database structures/ schemas, and software packages dedicated to different areas of applications based on data from high-throughput platforms preferably using desk top systems. More specifically this call would support R&D proposals that look into the following:-
- Development of analytical tools, software and pipelines for an integrated analysis using DNA, RNA, epigenomics and other omics data generated using various platforms next generation sequencing, microarray, epigenomics, proteomics, metabolomics etc. and integrating them with the large scale medical, agricultural, and ecological data to solve a particular scientific problem.
- Scaling up/optimization of an existing algorithm for significant improvements to solve a particular scientific problem involving large scale data with a proof of concept already established.
- Development of a platform/tool/software for data integration and /or comparison and/or interpretation and/or visualization.
- Development of newer database structures and/or schema for building, maintaining and sustaining a specific database that integrates data from multiple analytes, assays and experiments with a specific emphasis on the uniqueness of the database proposed and how it's going to become the de facto standard database in the field.
- Building user-friendly and menu-driven GUI for data processing, handling and analysis for both desktop and cloud-enabled big data applications. Development of algorithms towards data parallelization.
- Development of user-friendly mobile applications for data either towards making a decision for experimental design or implementation of high-throughput microarray and/or sequencing data in the lab.
Eligibility:
- Scientists working in the Universities/Academic Institutions/National Laboratories & Non-Profit Organizations, with sound scientific backgrounds and relevant publications in proposed area can submit applications.
- Proposals, which are interdisciplinary and integrative in nature, and focus on a specific area of application, will be given priority. Development of a collaborative proposal with experimental biologists is encouraged.
- Proposals involving analysis of NGS data for a single organism (even if it includes multiple samples) is not encouraged. DBT would welcome proposals involving hundreds or even thousands of multi-dimensional data points from a single organism involving a large sample set.
- Applicants must have prior approval from their organizations to submit the proposal.
Evaluation Criteria: Proposals will be judged based on scientific and technical merit, with emphasis placed on the delivery of a novel tool or package (but not repackaged existing tools) at the end of the project period addressing a particular scientific problem.
Mode of Submission: Proposals are to be submitted online only in the DBT's R & D format through eProMIS (http://dbtepromis.nic.in/Login.aspx) under Category of Area- ‘Bioinformatics, Systems and Computational Biology’ in the module “New Proposals Received Under Call”. The proposal should also clearly state that it is submitted under the “Call for Proposals’ as mentioned in DBT format. No hard copy submission will be accepted. For further information please contact “Dr. Vaishali Panjabi”, Scientist ‘D’ [vaishalip.dbt@nic.in].
Last Date of Submission: December 7, 2015
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