About the Company:
We are a global, science-led biopharmaceutical business and our innovative medicines are used by millions of patients worldwide.
Job Description - Associate Scientist/Scientist - Molecular & Cellular Neurobiology
We are seeking an Associate Scientist / Scientist who will support our efforts to identify new drug targets and transition early exploratory projects to portfolio targets. The successful candidate will work in a newly formed exploratory biology laboratory at the AstraZeneca/BioHub Gatehouse Park site in Waltham, MA and will provide expertise in cell- and molecular biology and screening approaches.
Duties and Responsibilities:
- Perform in vitro and in vivo experiments to support the development of assays for phenotypic screens, to enable target identification and validation, and to evaluate the mode of action and efficacy of novel drug candidates.
- Design, execute and analyze laboratory experiments in collaboration with scientists from internal and external partner groups.
- Prepare and maintain primary neuronal/glial cultures, mammalian cell lines and iPS-cells.
- Conduct cell-based and Biochemistry assays (including microimaging studies and high content analysis) in low and medium throughput
- Generate molecular-biology reagents (including gene-editing tools) to support mechanism of action studies.
- Provide general lab administrative support and guidance to junior scientists, graduate students and interns
Requirements:
- Minimally Bachelors and/or Masters Degree in Biology, Biochemistry, Neuroscience or related field
- Minimum 5 years (Masters) / 7 years (Bachelors) of hands-on experience working in a research laboratory
- Experience in Neuroscience and of drug discovery is preferred
- Expertise in a wide variety of techniques in Cell Biology, molecular biology and Biochemistry is required
- Expertise in development of phenotypic screens, microimaging and high content imaging approaches is highly desirable.
- Experience in the preparation and maintenance of primary neuronal/glial cultures essential. Experience with iPS cell (maintenance, differentiation) would be a plus but not essential.
- Experience of basic in vivo experiments (dosing, tissue collection) is desirable.
- Creative thinker with excellent troubleshooting skills and in depth knowledge of cell-culture technologies and experimental methodology.
- Pro-active and self-motivated person who enjoys working in a dynamic environment in a diverse team setting.
How to Apply:
If you meet the criteria above, please click the link below to be redirected to the applcation page.
Reference Number:1580016425
Date Advertisement Posted - 18th January 2016
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