About the University:
University College, Bristol existed from 1876 to 1909 and was the precursor to the University of Bristol.
Its history can be traced back to the efforts of John Percival, headmaster of Clifton College, to press for the establishment of such an institution. In 1872, Percival wrote to the Oxford colleges observing that the provinces lacked a university culture. The following year he produced a pamphlet called 'The Connection of the Universities and the Great Towns', which was well received by Benjamin Jowett, Master of Balliol College, Oxford. Jowett was to become a significant figure, both philosophically and financially, in the establishment of University College, Bristol.
Job Description:
The successful candidate will join the research group of Dr Jan Frayne in the School of Biochemistry to work on a Welcome Trust funded project to identify the molecular basis of enucleation defects in erythroid cells differentiated from pluripotent stem cells (PSCs).
The project is part of a £5M Welcome Trust funded consortium, the aim of which is to generate red blood cells (RBC) in vitro from PSCs for therapeutics (http://novosang.co.uk). The RBC research at Bristol University is also part of a NIHR Blood and Transplant Research Unit (BTRU) to advance pioneering research on the manufacture of red blood cells from stem cells and their translation from the lab to human trials.
The production of therapeutic quantities of cultured red blood cells in vitro is the ultimate goal for blood services and scientific laboratories worldwide. Pluripotent stem cells (PSCs) have the potential to provide an inexhaustible source of progenitors for such systems. However, although they can be differentiated efficiently down the erythroid pathway using established erythroid culture systems, they exhibit defects in terminal maturation and enucleation that need to be resolved. This position will investigate the molecular basis of these defects with the aim of using gene manipulation approaches to rectify.
Qualifications and Experience:
You should have a PhD in Biochemistry, Cell Biology or related discipline.
For informal enquiries please contact Dr Jan Frayne, 0117 3312127, Jan.Frayne@Bristol.ac.uk
The closing date for applications is midnight on Monday 25 January 2016.
Available documents:
How to Apply:
Apply online through University website.
Application Deadline - 25th January 2016
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