Doctoral student position with a doctoral grant in a Vascular Biology project on Molecular Mechanisms of Vascular complications of Diabetes with a focus on vein graft disease at Karolinska Institutet
Project :
- Physiological healing reaction takes place in the diseased vessel wall aimed to repair the vessel after an injury, noxious stimuli or altered physical forces. This process is disturbed in patients with metabolic syndrome, and high inflammatory state such as in subjects with diabetes, leading to the increased number of life-threatening complications. Although direct effects of glucose presumably play a role, indirect effects via stimulation of RAGE by AGEs formed during hyperglycemia are probably of greater importance. The overall aim of this research project is to further explore the specific roles of advanced glycation end products and GLP-1 in vascular repair. We also want to characterize the ability of GLP-1 agonists to improve the reendothelialization and healing of the vein grafts in diabetic conditions in vivo.
- The majority of the work will be conducted in Professor Ulf Hedin's Vascular Research laboratory at CMM. All the necessary equipment can be found at CMM and CMM is also a highly stimulating environment for a PhD student in the Cardiovascular field. 3 highly skilled laboratory technicians and 5 post docs are currently part of the group and will be able to support and assist the PhD student. The project has a strong translational character involving collaboration with the Department of Vascular Surgery, Karolinska University Hospital, where patients clinical data and samples will be collected.
Entry requirements :
- The applicant must meet the requirements for general eligibility for PhD studies at the Karolinska Institutet. Since diabetes and vein graft disease are pathophysiologically complex conditions a good knowledge of vascular medicine is an advantage. A candidate with some experience of laboratory work and especially advanced experimental animal procedures would be the most suitable. Experience in clinical work with peripheral vascular disease will be a merit, as well as approved course in Laboratory animal science. The candidate should be self-motivated and have good analytical and social skills. A good knowledge of Swedish is desirable, since the project involves retrieving clinical data from patient records. Medical doctors who would like to combine specialization and part time research are encouraged. Fluency in English is a requirement.
To meet the general entry requirements for third-cycle studies, an applicant must have
- taken a second-cycle qualification
- completed course requirements for at least 240 higher education credits, including at least 60 second-cycle higher education credits, or
- otherwise acquired essentially the same knowledge in or outside Sweden.
An applicant who met the general entry requirements for third-cycle studies before 1 July 2007 is regarded as having met the current requirements, though no longer than until the end of June 2015. Furthermore, English proficiency is required, for details see http://www.ki.se/doctoral/admission
A selection will be made among qualified applicants on the basis of the ability to benefit from third-cycle studies. Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to third-cycle studies in the subject
- The qualifications of the applicants will be evaluated on an overall basis.
Application process : An application must contain the following documents in Swedish or English:
- A personal letter and curriculum vitae
- A copy of a degree certificate and associated certificates
- A copy of a degree project and any previous publications
Deadline : 17.03.14
Recent Admission :